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After realizing the severity of the disease, Cuddy quarantines the maternity ward. In an effort to discover the source of the epidemic, House begins treating the children. However, when the kidneys of two of the children shut down, House is forced to test which drug caused the failure, resulting in one of the babies dying. Following an autopsy, the team discovers the presence of echovirus 11, CMV, and parvovirus B19 antibodies. They test the mothers and decide the cause of the epidemic is the Echovirus.
Recurring characters
Meanwhile, Foreman dates a pharmaceutical representative and House goes to a monster truck rally with Cameron.This episode features a cameo appearance by the series' director and executive producer Bryan Singer. A popular U.S. senator (Joe Morton) and presidential candidate succumbs to illness at a fundraiser and Vogler assigns House to his case. He also tells House he can keep his whole team if he endorses Vogler's pharmaceutical company. The Senator's initial diagnosis seems to point to AIDS, but House digs deeper for another answer.
Minor characters
With things back to normal, Cameron starts to let her feelings for House become known, but it is for no avail. She thinks he is totally unfeeling until House's ex-girlfriend Stacy Warner shows up, begging House to treat her husband. House successfully does so and finds himself in a position of letting his ex-girlfriend work at the hospital.
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Due to being bitten by the patient, Foreman is required to undergo rabies treatment himself. To give her peace as she dies, Foreman pretends to be her husband and forgives her. House and his team investigate an overweight ten-year-old girl (Jennifer Stone) who has a heart attack and her mother (Cynthia Ettinger) insists that House and his team look past her weight to find the diagnosis. It is revealed that Chase has been feeding Vogler information about House's cases.
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Dan suffers from an auditory hallucination during a procedure, however, ruling out House's diagnosis. Using coffee cups from the parents, House does an unauthorized paternity test and discovers that neither parent is biologically related to Dan. House flashbacks to a case he had earlier that involved a mother who did not want her baby to be vaccinated and theorizes that Dan is suffering from a measles virus contracted during his childhood. House confirms his diagnosis with a retinal biopsy and successfully cures Dan.
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But her situation strikes a chord with Dr. Wilson and he resolves to keep her from falling between the cracks. Meanwhile, House gets an audience of two medical students who are learning how to conduct medical histories. The patient is ultimately diagnosed with both a tuberculoma and rabies which is far beyond the point of treatment and the patient dies.
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Cameron notices a blood clot, which is removed, and MRI reveals an Arteriovenous malformation which is operated on restoring his ability to walk. Meanwhile, Foreman receives a lucrative job offer from John Henry's doctor, his former mentor. After returning from jogging with his best friend, Ed (Dominic Purcell) is uncharacteristically abused by his bedridden wife, Elise (Myndy Crist). House concludes that she either has rabbit fever from cooking rabbits or African sleeping sickness, which must have been sexually transmitted since neither of them has been to Africa. They both strongly deny having an affair so House starts treatment for rabbit fever.
House's team discover unused Ampicillin and frozen microwave burgers, supporting House's diagnosis. The tumor is too large to resect but House orders the team to shrink the tumor with an injection of ethanol so that the surgeon will operate. However, Lucille, in a decision House claims to be inconsistent with her schizophrenia, calls Social Services to take her son.
When House tells Cuddy and Vogler he chooses to fire Chase, Vogler rebuffs him and tells him to choose Foreman or Cameron instead. A severely broken arm reveals a bizarre case of bone loss and ends the comeback plans of major league pitcher Hank Wiggen (Scott Foley). House suspects Hank – with a history of drug abuse – is lying about using steroids, as his condition worsens. When Hank's kidneys start to fail, his wife (Meredith Monroe) offers to donate hers, but she will have to abort her early pregnancy, something Hank does not want. Eventually House finds out the wife suffers from loss of smell, indicating the pair have smoked cannabis which was grown on cadmium polluted soil.
She confesses to an affair with her husband's best friend, causing her husband to leave her. He has recently hired Eric Foreman, who, despite his considerable academic background, appears to have been hired because he was a juvenile delinquent. House plans on using him to break into patients' homes to look for diagnostic clues.
At the hospital, Rebecca suddenly loses her vision and suffers another seizure. Sister Augustine (Elizabeth Mitchell) arrives at the hospital with her hands covered in severe rash, which her fellow nuns think looks like stigmata and which House diagnoses as dermatitis caused by a dish soap allergy. When the antihistamines he gives her cause an asthma attack, House administers epinephrine, and she suffers a minor heart attack. House's team suspects that House made a mistake with the epinephrine, but when they try to find the source of her problems, she suffers hallucinations, convulsions and a rash appears on her leg. An investigation of the convent reveals figwort tea, which explains only the reaction with the epinephrine.
She is placed in a hypoallergenic room but inexplicably still has an allergic reaction. But when she begins shouting that she has God inside her, it allows House to find a copper IUD inside her uterus. The season followed Dr. House and his team as they solve a medical case each episode. The season's sub-plot revolved around billionaire Edward Vogler making a $100 million donation to the hospital. Billionaire entrepreneur Edward Vogler (Chi McBride) donates $100 million to Princeton-Plainsboro, officially becoming the new Chairman of the Board.
At the same time, House also deals with an elderly couple whose overactive sex life is seemingly causing them problems. House fights off a meningitis outbreak and Cuddy gives his team an hour to produce results after he singles out a young patient (Skye McCole Bartusiak)[29] who does not quite fit the criteria. House tries to get Cameron to return in the wake of Vogler's departure, but she demands House tell her why he really wants her back.
This resulted in his first Emmy Award nomination for "Outstanding Lead Actor in a Drama Series" for his role as Gregory House. The first season of House premiered on November 16, 2004 and ended on May 24, 2005.
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